2022 Ljubljana, Slovenia

A-01
Registration at the conference venue
Tuesday 09:30-17:30
A-02
Welcome reception with drinks and light snacks (no dinner)
Tuesday 19:30-21:30
B-01
Registration at the conference venue
Wednesday 08:00-08:45
B-02
Welcome and introduction
Wednesday 08:45-09:00
B-03
Keynote lecture
Wednesday 09:00-09:45
B-04 Iain Gardner
Pre-clinical and clinical applications of PBPK models for monoclonal antibodies and other large molecule modalities.
Wednesday 09:00-09:45
B-05
Coffee break, Poster and Software Session I
Wednesday 09:45-11:15
B-06
Immunogenicity
Wednesday 11:15-12:15
B-07 Hans Peter Grimm
Learn-and-Confirm in Quantitative Systems Pharmacology: Evaluation of an Immunogenicity Platform
Wednesday 11:15-11:35
B-08 Rory Leisegang
Immunogenicity dynamics and covariate effects after satralizumab administration predicted with a Hidden Markov Model
Wednesday 11:55-12:15
B-08 Alix Demaris
Towards understanding anti-infliximab antibody development to predict Crohn’s disease patients' underlying immunogenicity status
Wednesday 11:35-11:55
B-09
Lunch
Wednesday 12:15-13:45
B-10
Automatic Model Development
Wednesday 13:45-14:25
B-11 Xiaomei Chen
Development of a tool for fully automatic model development (AMD)
Wednesday 13:45-14:05
B-12 Marc Lavielle
SAMBA: a new algorithm for automatic construction of nonlinear mixed-effects models.
Wednesday 14:05-14:25
B-13
Model-Informed Precision Dosing
Wednesday 14:25-15:05
B-14 Ron Keizer
Composite Importance Sampling (CIS) for continuous learning in precision dosing
Wednesday 14:25-14:45
B-15 Benjamin Ribba
Population model-enhanced reinforcement learning to enable precision dosing: case study with dosing of propofol for sedation
Wednesday 14:45-15:05
B-16
Special Announcement
Wednesday 15:05-15:10
B-17
Coffee break, Poster and Software Session II
Wednesday 15:10-16:40
B-18
Modelling Other Pharmacological Aspects
Wednesday 16:40-17:20
B-19 Orwa Albitar
Pharmacometric Modeling of Drug Adverse Effects: An Application of Mixture Models in Schizophrenia Spectrum Disorder Patients Treated with Clozapine
Wednesday 16:40-17:00
B-20 Jurgen Langenhorst
An item response theory model with bounded integer subcomponents to describe the Mayo Clinic subscores in patients with ulcerative colitis
Wednesday 17:00-17:20
C-01
Lewis Sheiner Student Session
Thursday 08:30-09:50
C-02 Kamunkhwala Gausi
A semi-mechanistic model of the population pharmacokinetics and bactericidal activity of high-dose isoniazid against multi-drug-resistant tuberculosis
Thursday 08:30-08:55
C-03 Yu Fu
A translational cardiovascular systems model to quantify drug effects on contractility and other hemodynamic variables
Thursday 08:55-09:20
C-04 Soumya Perinparajah
Mathematically Modelling CD19+ B Cell Reconstitution After Insult to the Immune System: Paediatric Allogeneic Haematopoietic Stem Cell Transplantation, Rituximab Therapy and Epstein-Barr Viral Reactivation
Thursday 09:20-09:45
C-05
Presentation Lewis Sheiner Student Session Awards
Thursday 09:45-09:50
C-06
Coffee break, Poster and Software session III
Thursday 09:50-11:20
C-07
Infectious Diseases: SARS-CoV-2 & Tuberculosis
Thursday 11:20-12:40
C-08 Marie Alexandre
SARS-CoV-2 mechanistic correlates of protection in non-human primates: insight from modelling response to vaccines.
Thursday 11:20-11:40
C-09 Alexandra Lavalley-Morelle
Longitudinal biomarkers predicting death of hospitalized patients for SARS-COV-2 infection: a joint analysis with competing risks
Thursday 11:40-12:00
C-10 Jacqueline Ernest
Spatially and temporally resolved diffusion kinetics of bedaquiline and TBAJ-587 in hard-to-treat sites of TB disease
Thursday 12:00-12:20
C-11 Federico Reali
PBPK/PD modeling and machine learning approaches to support the development of new drugs and regimens against tuberculosis.
Thursday 12:20-12:40
C-12
ACoP Announcement
Thursday 12:40-12:45
C-13
Lunch
Thursday 12:45-14:15
C-14
Keynote Lecture
Thursday 14:15-15:00
C-15 Filippo Castiglione
Modeling biology by agents
Thursday 14:15-15:00
C-16
Coffee break, Poster, and Software Session IV
Thursday 15:00-16:30
C-17
Stuart Beal Methodology Session
Thursday 16:30-17:30
C-18 Sarah Baklouti
A methodology to de-shrink Empirical Bayes Estimates
Thursday 16:30-16:50
C-19 Thomas Bouillon
Dose selection by covariate assessment on the optimal dose for efficacy – application of machine learning in the context of PKPD
Thursday 16:50-17:10
C-20 Laura Zwep
Copula modeling for realistic virtual patient covariate simulation
Thursday 17:10-17:30
C-21
Social Event
Thursday 20:00-00:00
D-01
Oncology
Friday 09:15-10:35
D-02 Zinnia Parra-Guillen
A physiologically-based pharmacokinetic/pharmacodynamic framework to support clinical development of V937, a novel oncolytic virus
Friday 09:15-09:35
D-03 Marion Kerioui
Joint modelling of individual target lesions and survival to characterize the variability in the response to immunotherapy versus chemotherapy in advanced bladder cancer
Friday 09:35-09:55
D-04 Sebastien Benzekry
Supporting decision making and early prediction of survival for oncology drug development using a pharmacometrics-machine learning based model.
Friday 09:55-10:15
D-05 Sarah Lobet
Target-response relationship of bevacizumab may be more relevant than exposure-response - a target-mediated drug disposition (TMDD) model
Friday 10:15-0:35
D-06
Preview of PAGE 2023
Friday 10:35-10:40
D-07
Coffee break
Friday 10:40-11:15
D-08
Real-World Data in Oncology
Friday 11:15-11:55
D-09 Perrine Courlet
Modelling real-world tumor size dynamics based on electronic health records and image data in advanced melanoma patients receiving immunotherapy
Friday 11:15-11:35
D-10 Luca Marzano
Introducing a novel analytical framework for risk stratification of real-world data with survival and unsupervised machine learning. A small cell lung cancer SCLC study
Friday 11:35-11:55
D-11
Closing Remarks
Friday 11:55-12:05
D-12
Audience input for PAGE 2023 Scientific Programme
Friday 12:05-12:20