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Tuesday 7 June
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| 14:00-18:00 |
Registration at the Conference Venue |
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| 19:30-21:00 |
Welcome reception |
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Wednesday 8 June
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| 08:00-08:45 |
Registration |
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| 08:45-09:00 |
Welcome and Introduction |
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| 09:00-10:20 |
Immune response to drug treatment and immunotherapy |
Chair: Oscar Della Pasqua, Dinesh De Alwis
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| 09:00-09:40 |
Nigel Klein |
A biological perspective on immune response to drug treatment (intended and unintended effects) |
| 09:40-10:00 |
Hans Peter Grimm |
Intricate PK and PD for the novel immunocytokine CEA-IL2v and their pre-clinical to clinical translation |
| 10:00-10:20 |
Kirill Peskov |
Investigation of anti-CTLA-4 immuno-oncology therapy through a quantitative systems pharmacology model |
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| 10:20-11:40 |
Coffee break, Poster and Software session I |
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Posters in Group I (with poster numbers starting with I-) are accompanied by their presenter |
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| 11:40-12:20 |
Systems pharmacology |
Chair: Charlotte Kloft
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| 11:40-12:00 |
Kapil Gadkar |
A Six-Stage Workflow for Robust Application of Systems Pharmacology |
| 12:00-12:20 |
Rob van Wijk |
The zebrafish as model for translational systems pharmacology: expanding the allometric scale in vertebrates with five orders of magnitude |
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| 12:20-13:50 |
Lunch |
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| 13:50-15:05 |
Growth (I) |
Chair: Leon Aarons, Shasha Jumbe
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| 13:50-14:05 |
Shasha Jumbe |
Introduction to the Gates' Healthy Birth, Growth & Development knowledge integration project |
| 14:05-14:45 |
Louise Ryan |
Trajectory modelling based on early childhood longitudinal growth data |
| 14:45-15:05 |
Niclas Jonsson |
Determinants for physical growth patterns in low- and middle-income countries |
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| 15:05-15:10 |
Announcement of WCoP 2016 |
Nick Holford
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| 15:10-16:40 |
Tea break, Poster and Software session II |
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Posters in Group II (with poster numbers starting with II-) are accompanied by their presenter |
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| 16:40-17:20 |
Growth (II) |
Chair: Leon Aarons, Shasha Jumbe
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| 16:40-17:00 |
Mélanie Wilbaux |
Characterizing and Forecasting Individual Weight Changes in Term Neonates |
| 17:00-17:20 |
Nick Holford |
Growth and decline of body size and composition – Prediction of the transition from pre-diabetes to Type 2 diabetes in humans |
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| 17:40-18:20 |
Other applications |
Chair: Leon Aarons, Shasha Jumbe
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| 17:40-18:00 |
Thi Huyen Tram Nguyen |
The paradox of highly effective sofosbuvir combo therapy despite slow viral decline |
| 18:00-18:20 |
Rik Schoemaker |
Extrapolation of a Brivaracetam Exposure-Response Model from Adults to Children |
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| 18:30-18:50 |
Special surprise... |
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Thursday 9 June
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| 08:45-10:05 |
Lewis Sheiner Student Session |
Chair: Marylore Chenel, Aris Dokoumetzidis, Leonid Gibiansky
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| 08:45-09:10 |
Elin Svensson |
Bedaquiline's exposure-response relationship revealed through modeling of mycobacterial load |
| 09:10-09:35 |
Solène Desmée |
Joint modelling for nonlinear longitudinal PSA kinetics and survival data in metastatic prostate cancer patients |
| 09:35-10:00 |
Stein Schalkwijk |
A physiologically-based population pharmacokinetic analysis to assess a lower efavirenz dose of 400 mg once daily in HIV-infected pregnant women |
| 10.00-10.05 |
Presentation of Lewis Sheiner student session awards |
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| 10:05-11:30 |
Coffee break, Poster and Software session III |
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Posters in Group III (with poster numbers starting with III-) are accompanied by their presenter |
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| 11:30-12:30 |
Oncology
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Chair: Ana Ruiz
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| 11:30-11:50 |
Matts Kågedal |
Time-to-Event Modeling of Peripheral Neuropathy – Platform Mega-Analysis of Eight vc-MMAE Antibody-Drug Conjugates (ADCs) |
| 11:50-12:10 |
Lucy Hutchinson |
Mathematical modelling of transient tumour growth dynamics following anti-angiogenic therapy |
| 12:10-12:30 |
Maria Luisa Sardu |
Modelling of classified individual tumor lesions in metastatic colorectal cancer (mCRC) patients using delay differential equations |
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| 12:30-13:50 |
Lunch |
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| 13:50-14:35 |
Tutorial: Estimation methods
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Chair: France Mentré
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| 13:50-14:35 |
Robert Bauer |
An overview of Estimation-Maximization Algorithms Used in Population Analysis Methods |
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| 14:35-14:40 |
Announcement of ACoP7 |
Brian Corrigan
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| 14:40-16:00 |
Tea break, Poster and Software session IV |
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Posters in Group IV (with poster numbers starting with IV-) are accompanied by their presenter |
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| 16:00-17:20 |
Stuart Beal Methodology Session |
Chair: Paolo Magni
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| 16:00-16:20 |
Yevgen Ryeznik |
Adaptive dose finding for time-to-event outcomes with adaptive choice of patient number based on response rate |
| 16:20-16:40 |
Sebastian Wicha |
A general pharmacodynamic interaction model based on the Bliss Independence criterion |
| 16:40-17:00 |
Martin Fink |
Improving priors for human mAb linear PK parameters by using half-lives from pre-clinical studies |
| 17:00-17:20 |
David McDougall |
The Impact of Model Selection for Personalised Dosing |
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| 20:00-01:00 |
Social event: Buses depart from the Conference Venue at 19:30 |
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Friday 10 June
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| 09:00-10:00 |
Model-based approaches to aid in choice of dose and study design |
Chair: Justin Wilkins
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| 09:00-09:20 |
Lutz Harnisch |
Modelling and simulation of neurological endpoints (modified Rankin Scale [mRS] and National Institute of Health Stroke Scale [NIHSS]) to aid clinical trial design in intracerebral hemorrhage (ICH) |
| 09:20-09:40 |
Oliver Sander |
Model-based development of the secukinumab dosing regimen for the treatment of moderate-to-severe chronic plaque psoriasis |
| 09:40-10:00 |
Rasmus Vestergaard Juul |
Repeated time to event modelling of opioid consumption in postoperative pain |
| 10:00-10:20 |
Thu Thuy Nguyen |
Limited sampling strategy for a population pharmacokinetic modelling of cocktail of phenotyping drugs |
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| 10.20-10.30 |
Preview of PAGE 2017 |
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| 10:30-11:00 |
Coffee break and Software session |
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| 11:00-12:00 |
Central Nervous System Diseases |
Chair: Nick Holford
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| 11:00-11:20 |
Sylvie Retout |
How disease modeling and model-based meta-analyses contributed to understanding the path forward after dose discontinuation of a Phase III study in Alzheimer's disease |
| 11:20-11:40 |
Marc Vandemeulebroecke |
A longitudinal Item Response Theory model to characterize cognition over time in elderly subjects |
| 11:40-12:00 |
Simon Buatois |
Utilizing the items from the MDS-UPDRS score to increase drug effect detection power in de novo idiopathic Parkinson's disease |
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| 12.00-12.10 |
Closing remarks |
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| 12:10-12:30 |
Audience input for potential PAGE2017 topics |
